I've just come across the Email Overloaded blog. It's full of tips about how to manage your in-box better. The tips mainly assume you are using Outlook (so would suit WorkgroupShare users) but many would work with other email clients as well.
When version 4.5 of OfficeTalk is finally released I'll post some of my own tips for using it to manage your email. The reason for waiting is that some cool new features are being worked on which should improve on how I manage my email.